Ketobemidone Research Paper Example | Topics and Well Written Essays - 1500 words

Ketobemidone - Research Paper ExampleThis constitution explores the synonyms of Ketobemidone, its chemical structure, its discovery and synthesis, physical and chemical properties as well as its uses. Various Names for the chemical compound Ketobemidone is a compound with numerous names. The compound is also using other multiple synonyms such as 1-4-(3-Hydroxyphenyl)-1-methylpiperidin-4-yl-1-propanone Cetobemidone Ethyl 4-(3-hydroxyphenyl)-1-methylpiperidin-4-yl ketone Cliradon Cliradone Cetobemidon Cymidon Hoechst 10720 Ciba 7115 Ketobemidonum 1-4-(m-Hydroxyphenyl)-1-methyl-4-piperidyl-1-propanone 1-Propanone, 1-4-(3-hydroxyphenyl)-1-methyl-4-piperidinyl-1-Propanone, 1-4-(m-hydroxyphenyl)-1-methyl-4-piperidyl- NSC 117863 or A 21 Lundbeck1. The Chemical Structure of Ketobemidone The chemical structure of the compound is How Ketobemidone Was observed and Synthesized The history of synthetic drugs with morphia-like effect is relatively short, dating back only to 1939, when Eisleb pro duced the now famous 1-methyl-4-phenylpiperidine-4-carboxylic vitriolic ethyl ester.2 Eisleb unitedly with his colleagues first synthesized Ketobemidone in 1942 at I.G. Farbenindustries laboratory at Hoechst amidst cosmos War II. However, for many years, research had been on-going to muster synthetic substances with the same structure as morphine. Small, Eddy together with their co-workers at the United States Public Health service3 worked tirelessly to find these synthetic substances with morphine-like structure. The experiments were founded on the supposition that morphines painkiller effect was intrinsic in dibenzofuran, phenanthrene, dibenzofuran as well as carbazole nucleus, which were identified as components of morphine. Earlier attempts were however futile with no development of any synthetic compound with desirable painkiller effect. Organic chemistry experiments rarely yield expected results and products obtained usually come by chance. The analgesic occupation of 4- phenylpiperidines was find by chance in 1940s in the course of research by scientists to find antispasmodic characteristics on analogues of cocaine.4 The main focus of Eisleb and Schaumann was to find an alternative compound for atropine. The researchers discovered that the compounds had high levels of analgesic properties apart from their spasmolytic properties. Carboxylic dosage exhibited the best outcomes and was later sold in Germany as dolantin, which was wrong assumed to be non-addictive. As research intensified, several other compounds with structures like morphine were developed including methadone, which was discovered in Germany during the Second World War.5 The initial study of ketobemidone became available in print in 1946 later which it took short duration before being introduced in clinical medicine. In 1954, the Economic and Social Council urged governments to fall in producing and trading on ketobemidone arguing that it is a dangerous drug.6 Ketobemidone is synt hesized by alkylation of (3-methoxyphenyl) acetonitrile with bis (2-chloroethyl) methylamine, which is then reacted with ethylmagnesiumbromide. The resulting product is then O-demethylated with hydrobromic acid to form ketobemidone. 1-Methyl-4-(m-methoxy)phenyl-4-cyanopiperidine on reaction with ethyl magnesium bromide forms ketone intermediate, which on demethylation with hydrobromic acid affords ketobemidone.7 personal and Chemical Characteristics of Ketobemidone Physical Properties